BindingDB PrimarySearch

BDBM50138735 (S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-one::4-Isopropyl-3-methyl-2-((S)-3-methyl-piperidine-1-carbonyl)-2H-isoxazol-5-one::CHEMBL106126

SMILES: CC(C)c1c(C)n(oc1=O)C(=O)N1CCC[C@H](C)C1

InChI Key: InChIKey=XWESKOHENXWEAX-JTQLQIEISA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50138735
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hormone-sensitive lipase (HSL) (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Lipoprotein lipase (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was tested to inhibit lipoprotein lipase (LPL)				J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Pancreatic lipase (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was tested to inhibit pancreatic lipase (PL)				J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterases (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory concentration against butyrylcholinesterase.				J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone sensitive lipase (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant hormone sensitive lipase (HSL)				Bioorg Med Chem Lett 14: 3155-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.015 BindingDB Entry DOI: 10.7270/Q2NV9HQ5
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatic Lipase (HL) (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was tested to inhibit hepatic lipase (HL)				J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory concentration against acetylcholinesterase				J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (HSL) (Rattus norvegicus (Rat))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Jordan Curated by ChEMBL					Assay Description Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay				J Med Chem 51: 6478-94 (2008) Article DOI: 10.1021/jm800718k BindingDB Entry DOI: 10.7270/Q23778KJ
University of Jordan Curated by ChEMBL					More data for this Ligand-Target Pair
Hormone-sensitive lipase (HSL) (Homo sapiens (Human))	BDBM50138735 ((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of hormone sensitive lipase (HSL).				J Med Chem 47: 400-10 (2004) Article DOI: 10.1021/jm031004s BindingDB Entry DOI: 10.7270/Q2ZG6RN1
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair