BDBM50139048 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-{4-[2-((R)-1-hydroxy-ethyl)-phenyl]-piperazin-1-yl}-2-oxo-ethyl)-amide::CHEMBL351088

SMILES: C[C@@H](O)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1

InChI Key: InChIKey=HBZDOJHKUXRMEL-KPGYKUMBSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50139048   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139048 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES C[C@@H](O)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C31H35ClN4O3/c1-21(37)26-8-4-5-9-29(26)35-14-16-36(17-15-35)31(39)28(18-22-10-12-25(32)13-11-22)34-30(38)27-19-23-6-2-3-7-24(23)20-33-27/h2-13,21,27-28,33,37H,14-20H2,1H3,(H,34,38)/t21-,27-,28-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139048 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES C[C@@H](O)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C31H35ClN4O3/c1-21(37)26-8-4-5-9-29(26)35-14-16-36(17-15-35)31(39)28(18-22-10-12-25(32)13-11-22)34-30(38)27-19-23-6-2-3-7-24(23)20-33-27/h2-13,21,27-28,33,37H,14-20H2,1H3,(H,34,38)/t21-,27-,28-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Agonistic potency of the compound towards human melanocortin 4 receptor, determined by 50% maximum cAMP release				J Med Chem 47: 744-55 (2004) Article DOI: 10.1021/jm0304109 BindingDB Entry DOI: 10.7270/Q2DJ5F21
					More data for this Ligand-Target Pair