BDBM50139200 4-cyclopropylmethyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide::CHEMBL424338

SMILES: O=C1CN2CCN1Cc1cc(Oc3cc(Cn4cncc4C2)ccc3C#N)ccc1CC1CC1

InChI Key: InChIKey=MFPPMKRAKTUYMX-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50139200   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139200 (4-cyclopropylmethyl-23-oxo-8-oxa-1,15,17,21-tetraa...) Show SMILES O=C1CN2CCN1Cc1cc(Oc3cc(Cn4cncc4C2)ccc3C#N)ccc1CC1CC1 Show InChI InChI=1S/C27H27N5O2/c28-12-22-4-3-20-10-26(22)34-25-6-5-21(9-19-1-2-19)23(11-25)15-31-8-7-30(17-27(31)33)16-24-13-29-18-32(24)14-20/h3-6,10-11,13,18-19H,1-2,7-9,14-17H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-terminus of human K...				Bioorg Med Chem Lett 14: 639-43 (2004) BindingDB Entry DOI: 10.7270/Q2WM1CTK
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139200 (4-cyclopropylmethyl-23-oxo-8-oxa-1,15,17,21-tetraa...) Show SMILES O=C1CN2CCN1Cc1cc(Oc3cc(Cn4cncc4C2)ccc3C#N)ccc1CC1CC1 Show InChI InChI=1S/C27H27N5O2/c28-12-22-4-3-20-10-26(22)34-25-6-5-21(9-19-1-2-19)23(11-25)15-31-8-7-30(17-27(31)33)16-24-13-29-18-32(24)14-20/h3-6,10-11,13,18-19H,1-2,7-9,14-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled FTI from Farnesyltransferase in cultured Ha-ras transformed RAT1 cells.				Bioorg Med Chem Lett 14: 639-43 (2004) BindingDB Entry DOI: 10.7270/Q2WM1CTK
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139200 (4-cyclopropylmethyl-23-oxo-8-oxa-1,15,17,21-tetraa...) Show SMILES O=C1CN2CCN1Cc1cc(Oc3cc(Cn4cncc4C2)ccc3C#N)ccc1CC1CC1 Show InChI InChI=1S/C27H27N5O2/c28-12-22-4-3-20-10-26(22)34-25-6-5-21(9-19-1-2-19)23(11-25)15-31-8-7-30(17-27(31)33)16-24-13-29-18-32(24)14-20/h3-6,10-11,13,18-19H,1-2,7-9,14-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.				Bioorg Med Chem Lett 14: 639-43 (2004) BindingDB Entry DOI: 10.7270/Q2WM1CTK
					More data for this Ligand-Target Pair