BDBM50139407 4-{2-[2-((2R,6S)-2,6-Dimethyl-piperidin-1-yl)-ethyl]-benzofuran-5-yl}-benzonitrile::CHEMBL162591

SMILES: C[C@H]1CCC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N

InChI Key: InChIKey=DCIRDTIBHJXEGG-HDICACEKSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50139407   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50139407 (4-{2-[2-((2R,6S)-2,6-Dimethyl-piperidin-1-yl)-ethy...) Show SMILES C[C@H]1CCC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H26N2O/c1-17-4-3-5-18(2)26(17)13-12-23-15-22-14-21(10-11-24(22)27-23)20-8-6-19(16-25)7-9-20/h6-11,14-15,17-18H,3-5,12-13H2,1-2H3/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50139407 (4-{2-[2-((2R,6S)-2,6-Dimethyl-piperidin-1-yl)-ethy...) Show SMILES C[C@H]1CCC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H26N2O/c1-17-4-3-5-18(2)26(17)13-12-23-15-22-14-21(10-11-24(22)27-23)20-8-6-19(16-25)7-9-20/h6-11,14-15,17-18H,3-5,12-13H2,1-2H3/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139407 (4-{2-[2-((2R,6S)-2,6-Dimethyl-piperidin-1-yl)-ethy...) Show SMILES C[C@H]1CCC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H26N2O/c1-17-4-3-5-18(2)26(17)13-12-23-15-22-14-21(10-11-24(22)27-23)20-8-6-19(16-25)7-9-20/h6-11,14-15,17-18H,3-5,12-13H2,1-2H3/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139407 (4-{2-[2-((2R,6S)-2,6-Dimethyl-piperidin-1-yl)-ethy...) Show SMILES C[C@H]1CCC[C@@H](C)N1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H26N2O/c1-17-4-3-5-18(2)26(17)13-12-23-15-22-14-21(10-11-24(22)27-23)20-8-6-19(16-25)7-9-20/h6-11,14-15,17-18H,3-5,12-13H2,1-2H3/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes				Bioorg Med Chem Lett 14: 689-93 (2004) BindingDB Entry DOI: 10.7270/Q20C4V5H
					More data for this Ligand-Target Pair