BDBM50139584 4-(5-{[2-(2,4-Difluoro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL349203

SMILES: Fc1ccc(CN2Cc3ccccc3CC(NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c(F)c1

InChI Key: InChIKey=BQMDSBZYLBSEIH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50139584   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50139584 (4-(5-{[2-(2,4-Difluoro-benzyl)-3-oxo-2,3,4,5-tetra...) Show SMILES Fc1ccc(CN2Cc3ccccc3CC(NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c(F)c1 Show InChI InChI=1S/C29H25F2N5O/c30-25-10-9-24(27(31)12-25)18-35-17-23-4-2-1-3-22(23)11-28(29(35)37)34-15-26-14-33-19-36(26)16-21-7-5-20(13-32)6-8-21/h1-10,12,14,19,28,34H,11,15-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier Curated by ChEMBL					Assay Description Inhibition of farnesyltransferase				Bioorg Med Chem Lett 14: 767-71 (2004) BindingDB Entry DOI: 10.7270/Q2348JSW
					More data for this Ligand-Target Pair