Found 8 hits for monomerid = 50140367 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity against Coagulation factor X |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibitory concentration of compound was determined against thrombin |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity against Coagulation factor X |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Trypsin-1
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibitory concentration of compound was determined against trypsin |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibitory concentration against tissue type plasminogen activator |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Plasmin
(Rattus norvegicus) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibitory concentration of compound was determined against Plasmin |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Kallikrein-1 (KLK1)
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibitory concentration of compound was determined against kallikrein |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |
Vitamin K-dependent protein C
(Homo sapiens (Human)) | BDBM50140367
(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)Show SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O Show InChI InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibitory concentration of compound was determined against activated protein C (aPC) |
Bioorg Med Chem Lett 14: 1221-7 (2004)
Article DOI: 10.1016/j.bmcl.2003.12.053 BindingDB Entry DOI: 10.7270/Q2VD6XV5 |
More data for this Ligand-Target Pair | |