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BDBM50140434 2-(6-Chloro-naphthalen-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(imino-pyrrolidin-1-yl-methyl)-phenyl]-amide::CHEMBL281141

SMILES: Fc1cc(ccc1NC(=O)c1cc(nn1-c1ccc2cc(Cl)ccc2c1)C(F)(F)F)C(=N)N1CCCC1

InChI Key: InChIKey=WTUFYGNICPXDEV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50140434   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50140434
PNG
(2-(6-Chloro-naphthalen-2-yl)-5-trifluoromethyl-2H-...)
Show SMILES Fc1cc(ccc1NC(=O)c1cc(nn1-c1ccc2cc(Cl)ccc2c1)C(F)(F)F)C(=N)N1CCCC1
Show InChI InChI=1S/C26H20ClF4N5O/c27-18-6-3-16-12-19(7-4-15(16)11-18)36-22(14-23(34-36)26(29,30)31)25(37)33-21-8-5-17(13-20(21)28)24(32)35-9-1-2-10-35/h3-8,11-14,32H,1-2,9-10H2,(H,33,37)
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MMDB

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Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human coagulation factor X


Bioorg Med Chem Lett 14: 1229-34 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.054
BindingDB Entry DOI: 10.7270/Q2QN6664
More data for this
Ligand-Target Pair