BDBM50140791 1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-phenyl)-urea::CHEMBL28009

SMILES: Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br

InChI Key: InChIKey=JZBNYZCKVBXHSV-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50140791   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140791 (1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br Show InChI InChI=1S/C14H9Br2N3O2/c15-9-3-1-2-4-10(9)18-14(21)19-11-6-5-8(7-17)12(16)13(11)20/h1-6,20H,(H2,18,19,21)	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140791 (1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br Show InChI InChI=1S/C14H9Br2N3O2/c15-9-3-1-2-4-10(9)18-14(21)19-11-6-5-8(7-17)12(16)13(11)20/h1-6,20H,(H2,18,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Institute of Innovative Medicine Curated by ChEMBL					Assay Description Displacement of [125I]IL-8 from CXCR2 (unknown origin) stably expressed in CHO cells				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111853
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140791 (1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br Show InChI InChI=1S/C14H9Br2N3O2/c15-9-3-1-2-4-10(9)18-14(21)19-11-6-5-8(7-17)12(16)13(11)20/h1-6,20H,(H2,18,19,21)	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hangzhou Institute of Innovative Medicine Curated by ChEMBL					Assay Description Displacement of [125I]IL-8 from CXCR1 (unknown origin) stably expressed in CHO cells				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111853
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140791 (1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br Show InChI InChI=1S/C14H9Br2N3O2/c15-9-3-1-2-4-10(9)18-14(21)19-11-6-5-8(7-17)12(16)13(11)20/h1-6,20H,(H2,18,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
					More data for this Ligand-Target Pair