BDBM50141010 6-(5-Chloro-2-methyl-benzyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL34775

SMILES: Cc1ccc(Cl)cc1Cc1cnc2nc(N)nc(N)c2c1C

InChI Key: InChIKey=WCXBBZIDKOPNRB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50141010   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50141010 (6-(5-Chloro-2-methyl-benzyl)-5-methyl-pyrido[2,3-d...) Show SMILES Cc1ccc(Cl)cc1Cc1cnc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C16H16ClN5/c1-8-3-4-12(17)6-10(8)5-11-7-20-15-13(9(11)2)14(18)21-16(19)22-15/h3-4,6-7H,5H2,1-2H3,(H4,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium				J Med Chem 47: 1475-86 (2004) Article DOI: 10.1021/jm030438k BindingDB Entry DOI: 10.7270/Q2SJ1K14
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50141010 (6-(5-Chloro-2-methyl-benzyl)-5-methyl-pyrido[2,3-d...) Show SMILES Cc1ccc(Cl)cc1Cc1cnc2nc(N)nc(N)c2c1C Show InChI InChI=1S/C16H16ClN5/c1-8-3-4-12(17)6-10(8)5-11-7-20-15-13(9(11)2)14(18)21-16(19)22-15/h3-4,6-7H,5H2,1-2H3,(H4,18,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibitory concentration against dihdrofolate reductace enzyme of humans				J Med Chem 47: 1475-86 (2004) Article DOI: 10.1021/jm030438k BindingDB Entry DOI: 10.7270/Q2SJ1K14
					More data for this Ligand-Target Pair