null
SMILES: CC#CC(=O)Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
InChI Key: InChIKey=GPLSEURFJLQXHR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50141145 (But-2-ynoic acid [4-(3-chloro-4-fluoro-phenylamino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of epidermal growth factor receptor kinase autophosphorylation | Bioorg Med Chem Lett 14: 1411-6 (2004) Article DOI: 10.1016/j.bmcl.2004.01.034 BindingDB Entry DOI: 10.7270/Q2G161DC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50141145 (But-2-ynoic acid [4-(3-chloro-4-fluoro-phenylamino...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of epidermal growth factor receptor kinase autophosphorylation | Bioorg Med Chem Lett 14: 1411-6 (2004) Article DOI: 10.1016/j.bmcl.2004.01.034 BindingDB Entry DOI: 10.7270/Q2G161DC | |||||||||||
More data for this Ligand-Target Pair |