BDBM50141508 (E)-1-(3,4-Dimethoxy-phenyl)-3-[2-methoxy-5-(5-methyl-thiophen-2-yl)-phenyl]-propenone::CHEMBL35981

SMILES: COc1ccc(cc1OC)C(=O)\C=C\c1cc(ccc1OC)-c1ccc(C)s1

InChI Key: InChIKey=KULCPPSIGRYSKZ-RMKNXTFCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50141508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tumor necrosis factor receptor R1 (Homo sapiens (Human))	BDBM50141508 ((E)-1-(3,4-Dimethoxy-phenyl)-3-[2-methoxy-5-(5-met...) Show SMILES COc1ccc(cc1OC)C(=O)\C=C\c1cc(ccc1OC)-c1ccc(C)s1 Show InChI InChI=1S/C23H22O4S/c1-15-5-12-23(28-15)18-8-10-20(25-2)17(13-18)6-9-19(24)16-7-11-21(26-3)22(14-16)27-4/h5-14H,1-4H3/b9-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AtheroGenics, Inc. Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-induced VCAM-1 expression				Bioorg Med Chem Lett 14: 1513-7 (2004) Article DOI: 10.1016/j.bmcl.2004.01.021 BindingDB Entry DOI: 10.7270/Q2028QZK
					More data for this Ligand-Target Pair