BDBM50142026 3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one::3-(1-Methyl-1H-indol-3-ylmethylene)-1,3-dihydro-pyrrolo[3,2-b]pyridin-2-one::CHEMBL176544

SMILES: Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12

InChI Key: InChIKey=NXNQLECPAXXYTR-LCYFTJDESA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50142026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50142026 (3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3...) Show SMILES Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12 Show InChI InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of c-Raf1 kinase				Bioorg Med Chem Lett 14: 953-7 (2004) Article DOI: 10.1016/j.bmcl.2003.12.002 BindingDB Entry DOI: 10.7270/Q23R0TDF
					More data for this Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1 (Homo sapiens (Human))	BDBM50142026 (3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3...) Show SMILES Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12 Show InChI InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2 cyclin A				Bioorg Med Chem Lett 14: 953-7 (2004) Article DOI: 10.1016/j.bmcl.2003.12.002 BindingDB Entry DOI: 10.7270/Q23R0TDF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50142026 (3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3...) Show SMILES Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12 Show InChI InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Dongguk University Curated by ChEMBL					Assay Description Inhibition of human N- terminal GST-tagged TrkA cytoplasmic domain (436 to 790 residues) expressed in baculovirus infected sf21 cells using biotinyla...				Bioorg Med Chem 25: 389-396 (2017) Article DOI: 10.1016/j.bmc.2016.11.005 BindingDB Entry DOI: 10.7270/Q2JM2CNM
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50142026 (3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3...) Show SMILES Cn1cc(\C=C2/C(=O)Nc3cccnc23)c2ccccc12 Show InChI InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)				Bioorg Med Chem Lett 14: 953-7 (2004) Article DOI: 10.1016/j.bmcl.2003.12.002 BindingDB Entry DOI: 10.7270/Q23R0TDF
					More data for this Ligand-Target Pair