Found 9 hits for monomerid = 50142146 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description Inhibition of factor 10a |
J Med Chem 53: 6243-74 (2010)
Article DOI: 10.1021/jm100146h BindingDB Entry DOI: 10.7270/Q2CR5VBB |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Coagulation factor X |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Trypsin-1
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against trypsin. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against tissue type plasminogen activator. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against plasmin. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against thrombin. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against kallikrein |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against coagulation factor X. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Vitamin K-dependent protein C
(Homo sapiens (Human)) | BDBM50142146
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylam...)Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against activated protein C |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |