BDBM50142178 5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-trimethyl-guanidinomethyl)-benzoylamino]-benzamide::CHEMBL435741

SMILES: CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1

InChI Key: InChIKey=OLGYOUAJYXOHRV-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50142178   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vitamin K-dependent protein C (Homo sapiens (Human))	BDBM50142178 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-...) Show SMILES CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24Cl2N6O2/c1-27-24(28-2)32(3)14-15-4-6-16(7-5-15)22(33)30-20-10-8-17(25)12-19(20)23(34)31-21-11-9-18(26)13-29-21/h4-13H,14H2,1-3H3,(H,27,28)(H,30,33)(H,29,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against activated protein C				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50142178 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-...) Show SMILES CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24Cl2N6O2/c1-27-24(28-2)32(3)14-15-4-6-16(7-5-15)22(33)30-20-10-8-17(25)12-19(20)23(34)31-21-11-9-18(26)13-29-21/h4-13H,14H2,1-3H3,(H,27,28)(H,30,33)(H,29,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against tissue type plasminogen activator.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50142178 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-...) Show SMILES CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24Cl2N6O2/c1-27-24(28-2)32(3)14-15-4-6-16(7-5-15)22(33)30-20-10-8-17(25)12-19(20)23(34)31-21-11-9-18(26)13-29-21/h4-13H,14H2,1-3H3,(H,27,28)(H,30,33)(H,29,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against coagulation factor X.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50142178 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-...) Show SMILES CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24Cl2N6O2/c1-27-24(28-2)32(3)14-15-4-6-16(7-5-15)22(33)30-20-10-8-17(25)12-19(20)23(34)31-21-11-9-18(26)13-29-21/h4-13H,14H2,1-3H3,(H,27,28)(H,30,33)(H,29,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against trypsin.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50142178 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-...) Show SMILES CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24Cl2N6O2/c1-27-24(28-2)32(3)14-15-4-6-16(7-5-15)22(33)30-20-10-8-17(25)12-19(20)23(34)31-21-11-9-18(26)13-29-21/h4-13H,14H2,1-3H3,(H,27,28)(H,30,33)(H,29,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against thrombin.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50142178 (5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N',N''-...) Show SMILES CN\C(=N\C)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24Cl2N6O2/c1-27-24(28-2)32(3)14-15-4-6-16(7-5-15)22(33)30-20-10-8-17(25)12-19(20)23(34)31-21-11-9-18(26)13-29-21/h4-13H,14H2,1-3H3,(H,27,28)(H,30,33)(H,29,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against plasmin.				Bioorg Med Chem Lett 14: 989-93 (2004) Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD
					More data for this Ligand-Target Pair