Found 6 hits for monomerid = 50142183 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Trypsin-1
(Homo sapiens (Human)) | BDBM50142183
(2-[4-(4-Amino-piperidin-1-ylmethyl)-benzoylamino]-...)Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1 Show InChI InChI=1S/C25H25Cl2N5O2/c26-18-5-7-22(21(13-18)25(34)31-23-8-6-19(27)14-29-23)30-24(33)17-3-1-16(2-4-17)15-32-11-9-20(28)10-12-32/h1-8,13-14,20H,9-12,15,28H2,(H,30,33)(H,29,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against trypsin. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142183
(2-[4-(4-Amino-piperidin-1-ylmethyl)-benzoylamino]-...)Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1 Show InChI InChI=1S/C25H25Cl2N5O2/c26-18-5-7-22(21(13-18)25(34)31-23-8-6-19(27)14-29-23)30-24(33)17-3-1-16(2-4-17)15-32-11-9-20(28)10-12-32/h1-8,13-14,20H,9-12,15,28H2,(H,30,33)(H,29,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against coagulation factor X. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50142183
(2-[4-(4-Amino-piperidin-1-ylmethyl)-benzoylamino]-...)Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1 Show InChI InChI=1S/C25H25Cl2N5O2/c26-18-5-7-22(21(13-18)25(34)31-23-8-6-19(27)14-29-23)30-24(33)17-3-1-16(2-4-17)15-32-11-9-20(28)10-12-32/h1-8,13-14,20H,9-12,15,28H2,(H,30,33)(H,29,31,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against thrombin. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50142183
(2-[4-(4-Amino-piperidin-1-ylmethyl)-benzoylamino]-...)Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1 Show InChI InChI=1S/C25H25Cl2N5O2/c26-18-5-7-22(21(13-18)25(34)31-23-8-6-19(27)14-29-23)30-24(33)17-3-1-16(2-4-17)15-32-11-9-20(28)10-12-32/h1-8,13-14,20H,9-12,15,28H2,(H,30,33)(H,29,31,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against tissue type plasminogen activator. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50142183
(2-[4-(4-Amino-piperidin-1-ylmethyl)-benzoylamino]-...)Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1 Show InChI InChI=1S/C25H25Cl2N5O2/c26-18-5-7-22(21(13-18)25(34)31-23-8-6-19(27)14-29-23)30-24(33)17-3-1-16(2-4-17)15-32-11-9-20(28)10-12-32/h1-8,13-14,20H,9-12,15,28H2,(H,30,33)(H,29,31,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against plasmin. |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |
Vitamin K-dependent protein C
(Homo sapiens (Human)) | BDBM50142183
(2-[4-(4-Amino-piperidin-1-ylmethyl)-benzoylamino]-...)Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)CC1 Show InChI InChI=1S/C25H25Cl2N5O2/c26-18-5-7-22(21(13-18)25(34)31-23-8-6-19(27)14-29-23)30-24(33)17-3-1-16(2-4-17)15-32-11-9-20(28)10-12-32/h1-8,13-14,20H,9-12,15,28H2,(H,30,33)(H,29,31,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against activated protein C |
Bioorg Med Chem Lett 14: 989-93 (2004)
Article DOI: 10.1016/j.bmcl.2003.11.080 BindingDB Entry DOI: 10.7270/Q2X34WXD |
More data for this Ligand-Target Pair | |