BDBM50142302 6-Chloro-2-ethyl-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid ((S)-1-benzyl-2-oxo-ethyl)-amide::CHEMBL8378

SMILES: CCN1C(Cc2cc(Cl)ccc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O

InChI Key: InChIKey=DTCMEFWAOSYPAY-ZENAZSQFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50142302   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calpain1 (Homo sapiens (Human))	BDBM50142302 (6-Chloro-2-ethyl-1,1-dioxo-1,2,3,4-tetrahydro-1lam...) Show SMILES CCN1C(Cc2cc(Cl)ccc2S1(=O)=O)C(=O)N[C@@H](Cc1ccccc1)C=O Show InChI InChI=1S/C20H21ClN2O4S/c1-2-23-18(12-15-11-16(21)8-9-19(15)28(23,26)27)20(25)22-17(13-24)10-14-6-4-3-5-7-14/h3-9,11,13,17-18H,2,10,12H2,1H3,(H,22,25)/t17-,18?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description In vitro inhibitory activity against human calpain I; Not determined				Bioorg Med Chem Lett 14: 1035-8 (2004) Article DOI: 10.1016/j.bmcl.2003.11.037 BindingDB Entry DOI: 10.7270/Q27H1K45
					More data for this Ligand-Target Pair