BDBM50142346 CHEMBL41078::N-[4-(5-Chloro-2-hydroxy-benzyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-C,C,C-trifluoro-methanesulfonamide

SMILES: Oc1ccc(Cl)cc1Cc1c(NS(=O)(=O)C(F)(F)F)c(=O)[nH]c2ccc(cc12)C(F)(F)F

InChI Key: InChIKey=IGFJTSGNIPPHTD-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50142346   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily KQT member 2 (Mus musculus)	BDBM50142346 (CHEMBL41078 | N-[4-(5-Chloro-2-hydroxy-benzyl)-2-o...) Show SMILES Oc1ccc(Cl)cc1Cc1c(NS(=O)(=O)C(F)(F)F)c(=O)[nH]c2ccc(cc12)C(F)(F)F Show InChI InChI=1S/C18H11ClF6N2O4S/c19-10-2-4-14(28)8(5-10)6-12-11-7-9(17(20,21)22)1-3-13(11)26-16(29)15(12)27-32(30,31)18(23,24)25/h1-5,7,27-28H,6H2,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	663	n/a	n/a	n/a	n/a
The Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes				Bioorg Med Chem Lett 14: 1615-8 (2004) Article DOI: 10.1016/j.bmcl.2004.01.073 BindingDB Entry DOI: 10.7270/Q20V8C7Z
					More data for this Ligand-Target Pair