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BDBM50142528 CHEMBL296351::N-Benzothiazol-2-yl-3,4,5-trihydroxy-benzamide

SMILES: Oc1cc(cc(O)c1O)C(=O)Nc1nc2ccccc2s1

InChI Key: InChIKey=WHTLHKPXPPUCSN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50142528   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))		BDBM50142528
PNG
(CHEMBL296351 | N-Benzothiazol-2-yl-3,4,5-trihydrox...)
Show SMILES Oc1cc(cc(O)c1O)C(=O)Nc1nc2ccccc2s1
Show InChI InChI=1S/C14H10N2O4S/c17-9-5-7(6-10(18)12(9)19)13(20)16-14-15-8-3-1-2-4-11(8)21-14/h1-6,17-19H,(H,15,16,20)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.20E+3n/an/an/an/an/an/a



Kumamoto University

Curated by ChEMBL


Assay Description
Inhibitory concentration against relaxation activity of DNA topoisomerase I by detecting the conversion of supercoiled pBR322 DNA to its relaxed form

Bioorg Med Chem Lett 14: 1669-72 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.060
BindingDB Entry DOI: 10.7270/Q2GX4B0X
More data for this
Ligand-Target Pair