BDBM50142759 (R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethyl)phenyl)methanesulfonamide::CHEMBL412885::N-(4-tert-butylbenzyl)-N'-{(1R)-1-[4-(methylsulfonylamino)phenyl]ethyl}thiourea::N-(4-{(R)-1-[3-(4-tert-Butyl-benzyl)-thioureido]-ethyl}-phenyl)-methanesulfonamide
SMILES: C[C@@H](NC(=S)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)cc1
InChI Key: InChIKey=MRGDOZGZFFCDRJ-OAHLLOKOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sookmyung Women's University Curated by ChEMBL | Assay Description Agonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as intracellular 45Ca2+ influx by scintillation counting | Bioorg Med Chem 18: 111-6 (2010) Article DOI: 10.1016/j.bmc.2009.11.014 BindingDB Entry DOI: 10.7270/Q2TQ61NH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Sookmyung Women's University Curated by ChEMBL | Assay Description Antagonist activity at TRPV1 in neonatal rat DRG neurons assessed as inhibition of capsaicin-induced intracellular calcium after 10 mins in presence ... | Bioorg Med Chem Lett 28: 2080-2083 (2018) Article DOI: 10.1016/j.bmcl.2018.04.044 BindingDB Entry DOI: 10.7270/Q2NZ8B44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Sookmyung Women's University Curated by ChEMBL | Assay Description Agonist activity at TRPV1 in neonatal rat DRG neurons assessed as increase in calcium influx after 10 mins in presence of 45Ca2+ by Beckman CP scinti... | Bioorg Med Chem Lett 28: 2080-2083 (2018) Article DOI: 10.1016/j.bmcl.2018.04.044 BindingDB Entry DOI: 10.7270/Q2NZ8B44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50142759 ((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Sookmyung Women's University Curated by ChEMBL | Assay Description Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated intracellular 45Ca2+ influx by scintillat... | Bioorg Med Chem 18: 111-6 (2010) Article DOI: 10.1016/j.bmc.2009.11.014 BindingDB Entry DOI: 10.7270/Q2TQ61NH | |||||||||||
More data for this Ligand-Target Pair |