BDBM50142895 2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole::2-phenylimidazoline::2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-fluoro-phenyl}-4,5-dihydro-1H-imidazole::CHEMBL40711::ML-253764

SMILES: COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1

InChI Key: InChIKey=WCPPZGPJRHLSKP-UHFFFAOYSA-N

Data: 12 KI  12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50142895   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	151	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligand				Bioorg Med Chem Lett 15: 2541-6 (2005) Article DOI: 10.1016/j.bmcl.2005.03.053 BindingDB Entry DOI: 10.7270/Q22Z1527
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Mus musculus)	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...				J Med Chem 47: 1602-4 (2004) Article DOI: 10.1021/jm034244g BindingDB Entry DOI: 10.7270/Q2JQ10GG
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from human wild type MC4R expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	890	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.82E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.99E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cells				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	355	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R I125L expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	708	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of alpha-MSH-induced cAMP production by ELISA				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulation				J Med Chem 49: 911-22 (2006) Article DOI: 10.1021/jm050780s BindingDB Entry DOI: 10.7270/Q2D21ZCX
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50142895 (2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...) Show SMILES COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |t:20| Show InChI InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Antagonist activity at MC4R (unknown origin)				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair