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BDBM50143281 3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine::CHEMBL55138

SMILES: Ic1cncc(O[C@H]2CCN2)c1

InChI Key: InChIKey=KSOZTGQWGPTPSV-QMMMGPOBSA-N

Data: 5 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50143281
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-2/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50143281 (3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine \| CHEMBL5...) Show SMILES Ic1cncc(O[C@H]2CCN2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.0310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50143281 (3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine \| CHEMBL5...) Show SMILES Ic1cncc(O[C@H]2CCN2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.0620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-3/Beta-2 (Rattus norvegicus (Rat))	BDBM50143281 (3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine \| CHEMBL5...) Show SMILES Ic1cncc(O[C@H]2CCN2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-4 subunit (Rattus norvegicus (Rat))	BDBM50143281 (3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine \| CHEMBL5...) Show SMILES Ic1cncc(O[C@H]2CCN2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-3/Beta-4 (Rattus norvegicus (Rat))	BDBM50143281 (3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine \| CHEMBL5...) Show SMILES Ic1cncc(O[C@H]2CCN2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University School of Medicine Curated by ChEMBL					Assay Description Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligand				Bioorg Med Chem Lett 14: 1845-8 (2004) Article DOI: 10.1016/j.bmcl.2003.09.105 BindingDB Entry DOI: 10.7270/Q2TB17G2
Georgetown University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair