BindingDB PrimarySearch

null

SMILES: Fc1ccc(cc1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1

InChI Key: InChIKey=YSLMGFFVMWWPSA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50143661
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Binding affinity for human Alpha-1D adrenergic receptor				J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K
Lundbeck Research USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity to the adrenergic receptor alpha-1D of rat aorta				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
Recordati s.p.a. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Binding affinity for human 5-hydroxytryptamine 1A receptor				J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K
Lundbeck Research USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Binding affinity for rat Dopamine receptor D3				J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K
Lundbeck Research USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	153	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Recordati s.p.a. Curated by ChEMBL					Assay Description Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli...				J Med Chem 47: 1900-18 (2004) Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35
Recordati s.p.a. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1B adrenergic receptor (Homo sapiens (Human))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	255	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Binding affinity for human Alpha-1B adrenergic receptor				J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K
Lundbeck Research USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Binding affinity for human Alpha-1A adrenergic receptor				J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K
Lundbeck Research USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50143661 (8-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Binding affinity for human Dopamine receptor D2				J Med Chem 48: 3076-9 (2005) Article DOI: 10.1021/jm0491391 BindingDB Entry DOI: 10.7270/Q2445M0K
Lundbeck Research USA, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair