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BDBM50144100 CHEMBL62758::[4-(6-Bromo-naphthalene-2-sulfonyl)-piperazin-1-yl]-[4-(1-ethyl-4,5-dihydro-1H-imidazol-2-yl)-phenyl]-methanone

SMILES: CCN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccc2cc(Br)ccc2c1

InChI Key: InChIKey=KBEXUSAYOYHRJR-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50144100   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50144100
PNG
(CHEMBL62758 | [4-(6-Bromo-naphthalene-2-sulfonyl)-...)
Show SMILES CCN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccc2cc(Br)ccc2c1 |c:5|
Show InChI InChI=1S/C26H27BrN4O3S/c1-2-29-12-11-28-25(29)19-3-5-20(6-4-19)26(32)30-13-15-31(16-14-30)35(33,34)24-10-8-21-17-23(27)9-7-22(21)18-24/h3-10,17-18H,2,11-16H2,1H3
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MMDB

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Similars

Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair