BDBM50144597 CHEMBL3759830

SMILES: COc1ccc(cc1)C(=O)Nc1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1

InChI Key: InChIKey=YIQIIWTUQHYAID-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50144597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50144597 (CHEMBL3759830) Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1 Show InChI InChI=1S/C31H36N6O4/c1-36-14-16-37(17-15-36)13-4-18-41-29-20-27-26(19-28(29)40-3)30(33-21-32-27)34-23-7-9-24(10-8-23)35-31(38)22-5-11-25(39-2)12-6-22/h5-12,19-21H,4,13-18H2,1-3H3,(H,35,38)(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...				Eur J Med Chem 109: 371-9 (2016) BindingDB Entry DOI: 10.7270/Q2M32XKS
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50144597 (CHEMBL3759830) Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(Nc2ncnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)cc1 Show InChI InChI=1S/C31H36N6O4/c1-36-14-16-37(17-15-36)13-4-18-41-29-20-27-26(19-28(29)40-3)30(33-21-32-27)34-23-7-9-24(10-8-23)35-31(38)22-5-11-25(39-2)12-6-22/h5-12,19-21H,4,13-18H2,1-3H3,(H,35,38)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...				Eur J Med Chem 109: 371-9 (2016) BindingDB Entry DOI: 10.7270/Q2M32XKS
					More data for this Ligand-Target Pair