BDBM50144601 CHEMBL3758749

SMILES: COc1cc2c(Nc3ccc(NC(=O)c4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key: InChIKey=BJPTWWXRRXRJMX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50144601   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50144601 (CHEMBL3758749) Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C30H33ClN6O3/c1-36-12-14-37(15-13-36)11-4-16-40-28-19-26-25(18-27(28)39-2)29(33-20-32-26)34-23-7-9-24(10-8-23)35-30(38)21-5-3-6-22(31)17-21/h3,5-10,17-20H,4,11-16H2,1-2H3,(H,35,38)(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human VEGFR-2 preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ...				Eur J Med Chem 109: 371-9 (2016) BindingDB Entry DOI: 10.7270/Q2M32XKS
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50144601 (CHEMBL3758749) Show SMILES COc1cc2c(Nc3ccc(NC(=O)c4cccc(Cl)c4)cc3)ncnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C30H33ClN6O3/c1-36-12-14-37(15-13-36)11-4-16-40-28-19-26-25(18-27(28)39-2)29(33-20-32-26)34-23-7-9-24(10-8-23)35-30(38)21-5-3-6-22(31)17-21/h3,5-10,17-20H,4,11-16H2,1-2H3,(H,35,38)(H,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human EGFR preincubated for 10 mins followed by addition of FAM-labeled peptide and incubated for 10 mins by Caliper motility shift ass...				Eur J Med Chem 109: 371-9 (2016) BindingDB Entry DOI: 10.7270/Q2M32XKS
					More data for this Ligand-Target Pair