BDBM50144624 (5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-furan-2-ylmethyl)-N-hydroxyurea::CHEMBL307609

SMILES: NC(=O)N(O)Cc1ccc(CN2CCN(CC2)[C@H](c2ccccc2)c2ccc(Cl)cc2)o1

InChI Key: InChIKey=WTUOCEYWCJZOOS-HSZRJFAPSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50144624   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM50144624 ((5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-pipera...) Show SMILES NC(=O)N(O)Cc1ccc(CN2CCN(CC2)[C@H](c2ccccc2)c2ccc(Cl)cc2)o1 Show InChI InChI=1S/C24H27ClN4O3/c25-20-8-6-19(7-9-20)23(18-4-2-1-3-5-18)28-14-12-27(13-15-28)16-21-10-11-22(32-21)17-29(31)24(26)30/h1-11,23,31H,12-17H2,(H2,26,30)/t23-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
UCB Research Curated by ChEMBL					Assay Description In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells				Bioorg Med Chem Lett 14: 2265-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.005 BindingDB Entry DOI: 10.7270/Q2BV7G2P
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50144624 ((5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-pipera...) Show SMILES NC(=O)N(O)Cc1ccc(CN2CCN(CC2)[C@H](c2ccccc2)c2ccc(Cl)cc2)o1 Show InChI InChI=1S/C24H27ClN4O3/c25-20-8-6-19(7-9-20)23(18-4-2-1-3-5-18)28-14-12-27(13-15-28)16-21-10-11-22(32-21)17-29(31)24(26)30/h1-11,23,31H,12-17H2,(H2,26,30)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
UCB Research Curated by ChEMBL					Assay Description In vitro inhibitory activity against 5-lipoxygenase in a human whole blood assay				Bioorg Med Chem Lett 14: 2265-8 (2004) Article DOI: 10.1016/j.bmcl.2004.02.005 BindingDB Entry DOI: 10.7270/Q2BV7G2P
					More data for this Ligand-Target Pair