BDBM50145379 CHEMBL3765769

SMILES: COC(=O)c1c(Nc2ccc(C)cc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C

InChI Key: InChIKey=FCLFAWALTWFASK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145379   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145379 (CHEMBL3765769) Show SMILES COC(=O)c1c(Nc2ccc(C)cc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C23H21N3O5/c1-12-5-7-13(8-6-12)24-18-17(23(29)30-4)19-22(21(28)20(18)27)31-16-11-14(26(2)3)9-10-15(16)25-19/h5-11,24,28H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair