BDBM50146326 (E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-1H-indazol-5-yl]-but-2-enoic acid::CHEMBL91979

SMILES: CCOc1c(cc(cc1-c1[nH]nc2ccc(cc12)C(C)=CC(O)=O)C(C)C)C(C)C

InChI Key: InChIKey=LWXJNLCQFQPZKN-UHFFFAOYSA-N

Data: 2 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50146326   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50146326 ((E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-1H-inda...) Show SMILES CCOc1c(cc(cc1-c1[nH]nc2ccc(cc12)C(C)=CC(O)=O)C(C)C)C(C)C |w:20.23| Show InChI InChI=1S/C25H30N2O3/c1-7-30-25-19(15(4)5)12-18(14(2)3)13-21(25)24-20-11-17(16(6)10-23(28)29)8-9-22(20)26-27-24/h8-15H,7H2,1-6H3,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	69	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effective concentration for antagonistic activity against RXR-alpha expressed in CV-1 cells				Bioorg Med Chem Lett 14: 2759-63 (2004) Article DOI: 10.1016/j.bmcl.2004.03.073 BindingDB Entry DOI: 10.7270/Q2513XNB
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50146326 ((E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-1H-inda...) Show SMILES CCOc1c(cc(cc1-c1[nH]nc2ccc(cc12)C(C)=CC(O)=O)C(C)C)C(C)C |w:20.23| Show InChI InChI=1S/C25H30N2O3/c1-7-30-25-19(15(4)5)12-18(14(2)3)13-21(25)24-20-11-17(16(6)10-23(28)29)8-9-22(20)26-27-24/h8-15H,7H2,1-6H3,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to displace [3H]-ATRA from Retinoic acid receptor gamma in CV-1 cells				Bioorg Med Chem Lett 14: 2759-63 (2004) Article DOI: 10.1016/j.bmcl.2004.03.073 BindingDB Entry DOI: 10.7270/Q2513XNB
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50146326 ((E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-1H-inda...) Show SMILES CCOc1c(cc(cc1-c1[nH]nc2ccc(cc12)C(C)=CC(O)=O)C(C)C)C(C)C |w:20.23| Show InChI InChI=1S/C25H30N2O3/c1-7-30-25-19(15(4)5)12-18(14(2)3)13-21(25)24-20-11-17(16(6)10-23(28)29)8-9-22(20)26-27-24/h8-15H,7H2,1-6H3,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	235	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity in CV-1 cells expressing RXR-alpha				Bioorg Med Chem Lett 14: 2759-63 (2004) Article DOI: 10.1016/j.bmcl.2004.03.073 BindingDB Entry DOI: 10.7270/Q2513XNB
					More data for this Ligand-Target Pair