BindingDB PrimarySearch

BDBM50146473 2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-amino)-3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-propylidene}-piperidin-1-yl ester::CHEMBL95414

SMILES: [#6]-c1cc(-[#6]-[#8]-c2ccc(cc2)S(=O)(=O)[#6]-[#6](\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#8]-[#6](=O)C([#6])([#6])[#6])-[#7](-[#8])-[#6]=O)c2ccccc2n1

InChI Key: InChIKey=FUYGKZYSHSZHFI-UHFFFAOYSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50146473
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Matrix metalloproteinase 17 (Homo sapiens (Human))	BDBM50146473 (2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-a...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-17				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50146473 (2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-9				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50146473 (2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-2				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50146473 (2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-3				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50146473 (2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of Tumor necrosis factor alpha converting enzyme				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50146473 (2,2-Dimethyl-propionic acid 4-{2-(formyl-hydroxy-a...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-13				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair