BDBM50146480 CHEMBL329967::N-Hydroxy-N-{1-(4-hydroxyimino-cyclohexylmethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide

SMILES: Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1

InChI Key: InChIKey=AXBBWELSCMNUPM-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50146480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase 17 (Homo sapiens (Human))	BDBM50146480 (CHEMBL329967 | N-Hydroxy-N-{1-(4-hydroxyimino-cycl...) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(-1.77,-1.66,;-3.1,-.89,;-3.1,.67,;-4.43,1.42,;-4.45,2.96,;-3.12,3.73,;-1.79,2.98,;-1.79,1.44,;-.44,.68,;.89,1.46,;.87,3,;-.46,3.77,;2.22,.69,;2.99,2.03,;1.47,-.64,;3.55,-.08,;4.91,.65,;4.9,2.19,;6.21,3,;6.17,4.53,;7.47,5.34,;8.83,4.62,;8.89,3.08,;7.57,2.26,;10.13,5.44,;11.5,4.71,;6.21,-.15,;7.57,.58,;6.17,-1.69,;7.47,-2.5,;-5.76,.65,;-7.11,1.42,;-8.44,.65,;-8.44,-.89,;-7.09,-1.66,;-5.76,-.89,;-4.43,-1.66,)| Show InChI InChI=1S/C27H31N3O6S/c1-19-14-21(26-4-2-3-5-27(26)28-19)16-36-24-10-12-25(13-11-24)37(34,35)17-23(30(33)18-31)15-20-6-8-22(29-32)9-7-20/h2-5,10-14,18,20,22-23,33H,6-9,15-17H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-17				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50146480 (CHEMBL329967 | N-Hydroxy-N-{1-(4-hydroxyimino-cycl...) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(-1.77,-1.66,;-3.1,-.89,;-3.1,.67,;-4.43,1.42,;-4.45,2.96,;-3.12,3.73,;-1.79,2.98,;-1.79,1.44,;-.44,.68,;.89,1.46,;.87,3,;-.46,3.77,;2.22,.69,;2.99,2.03,;1.47,-.64,;3.55,-.08,;4.91,.65,;4.9,2.19,;6.21,3,;6.17,4.53,;7.47,5.34,;8.83,4.62,;8.89,3.08,;7.57,2.26,;10.13,5.44,;11.5,4.71,;6.21,-.15,;7.57,.58,;6.17,-1.69,;7.47,-2.5,;-5.76,.65,;-7.11,1.42,;-8.44,.65,;-8.44,-.89,;-7.09,-1.66,;-5.76,-.89,;-4.43,-1.66,)| Show InChI InChI=1S/C27H31N3O6S/c1-19-14-21(26-4-2-3-5-27(26)28-19)16-36-24-10-12-25(13-11-24)37(34,35)17-23(30(33)18-31)15-20-6-8-22(29-32)9-7-20/h2-5,10-14,18,20,22-23,33H,6-9,15-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-9				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50146480 (CHEMBL329967 | N-Hydroxy-N-{1-(4-hydroxyimino-cycl...) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(-1.77,-1.66,;-3.1,-.89,;-3.1,.67,;-4.43,1.42,;-4.45,2.96,;-3.12,3.73,;-1.79,2.98,;-1.79,1.44,;-.44,.68,;.89,1.46,;.87,3,;-.46,3.77,;2.22,.69,;2.99,2.03,;1.47,-.64,;3.55,-.08,;4.91,.65,;4.9,2.19,;6.21,3,;6.17,4.53,;7.47,5.34,;8.83,4.62,;8.89,3.08,;7.57,2.26,;10.13,5.44,;11.5,4.71,;6.21,-.15,;7.57,.58,;6.17,-1.69,;7.47,-2.5,;-5.76,.65,;-7.11,1.42,;-8.44,.65,;-8.44,-.89,;-7.09,-1.66,;-5.76,-.89,;-4.43,-1.66,)| Show InChI InChI=1S/C27H31N3O6S/c1-19-14-21(26-4-2-3-5-27(26)28-19)16-36-24-10-12-25(13-11-24)37(34,35)17-23(30(33)18-31)15-20-6-8-22(29-32)9-7-20/h2-5,10-14,18,20,22-23,33H,6-9,15-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-2				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50146480 (CHEMBL329967 | N-Hydroxy-N-{1-(4-hydroxyimino-cycl...) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(-1.77,-1.66,;-3.1,-.89,;-3.1,.67,;-4.43,1.42,;-4.45,2.96,;-3.12,3.73,;-1.79,2.98,;-1.79,1.44,;-.44,.68,;.89,1.46,;.87,3,;-.46,3.77,;2.22,.69,;2.99,2.03,;1.47,-.64,;3.55,-.08,;4.91,.65,;4.9,2.19,;6.21,3,;6.17,4.53,;7.47,5.34,;8.83,4.62,;8.89,3.08,;7.57,2.26,;10.13,5.44,;11.5,4.71,;6.21,-.15,;7.57,.58,;6.17,-1.69,;7.47,-2.5,;-5.76,.65,;-7.11,1.42,;-8.44,.65,;-8.44,-.89,;-7.09,-1.66,;-5.76,-.89,;-4.43,-1.66,)| Show InChI InChI=1S/C27H31N3O6S/c1-19-14-21(26-4-2-3-5-27(26)28-19)16-36-24-10-12-25(13-11-24)37(34,35)17-23(30(33)18-31)15-20-6-8-22(29-32)9-7-20/h2-5,10-14,18,20,22-23,33H,6-9,15-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of Tumor necrosis factor alpha converting enzyme				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50146480 (CHEMBL329967 | N-Hydroxy-N-{1-(4-hydroxyimino-cycl...) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(-1.77,-1.66,;-3.1,-.89,;-3.1,.67,;-4.43,1.42,;-4.45,2.96,;-3.12,3.73,;-1.79,2.98,;-1.79,1.44,;-.44,.68,;.89,1.46,;.87,3,;-.46,3.77,;2.22,.69,;2.99,2.03,;1.47,-.64,;3.55,-.08,;4.91,.65,;4.9,2.19,;6.21,3,;6.17,4.53,;7.47,5.34,;8.83,4.62,;8.89,3.08,;7.57,2.26,;10.13,5.44,;11.5,4.71,;6.21,-.15,;7.57,.58,;6.17,-1.69,;7.47,-2.5,;-5.76,.65,;-7.11,1.42,;-8.44,.65,;-8.44,-.89,;-7.09,-1.66,;-5.76,-.89,;-4.43,-1.66,)| Show InChI InChI=1S/C27H31N3O6S/c1-19-14-21(26-4-2-3-5-27(26)28-19)16-36-24-10-12-25(13-11-24)37(34,35)17-23(30(33)18-31)15-20-6-8-22(29-32)9-7-20/h2-5,10-14,18,20,22-23,33H,6-9,15-17H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-13				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50146480 (CHEMBL329967 | N-Hydroxy-N-{1-(4-hydroxyimino-cycl...) Show SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(CC2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(-1.77,-1.66,;-3.1,-.89,;-3.1,.67,;-4.43,1.42,;-4.45,2.96,;-3.12,3.73,;-1.79,2.98,;-1.79,1.44,;-.44,.68,;.89,1.46,;.87,3,;-.46,3.77,;2.22,.69,;2.99,2.03,;1.47,-.64,;3.55,-.08,;4.91,.65,;4.9,2.19,;6.21,3,;6.17,4.53,;7.47,5.34,;8.83,4.62,;8.89,3.08,;7.57,2.26,;10.13,5.44,;11.5,4.71,;6.21,-.15,;7.57,.58,;6.17,-1.69,;7.47,-2.5,;-5.76,.65,;-7.11,1.42,;-8.44,.65,;-8.44,-.89,;-7.09,-1.66,;-5.76,-.89,;-4.43,-1.66,)| Show InChI InChI=1S/C27H31N3O6S/c1-19-14-21(26-4-2-3-5-27(26)28-19)16-36-24-10-12-25(13-11-24)37(34,35)17-23(30(33)18-31)15-20-6-8-22(29-32)9-7-20/h2-5,10-14,18,20,22-23,33H,6-9,15-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Kaken Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of matrix metalloproteinase-3				Bioorg Med Chem Lett 14: 2897-900 (2004) Article DOI: 10.1016/j.bmcl.2004.03.048 BindingDB Entry DOI: 10.7270/Q27S7N7C
					More data for this Ligand-Target Pair