BDBM50146545 2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-2-ylamino]-4-methoxy-thiazole-5-carboxylic acid ethyl ester::CHEMBL100779
SMILES: CCOC(=O)c1sc(Nc2nc(NCc3ccc(OC)c(OC)c3)c3n(CC)cnc3n2)nc1OC
InChI Key: InChIKey=UIVOBRCKHLHLLQ-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50146545 (2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against phosphodiesterase 5 (PDE5) from human platelet | Bioorg Med Chem Lett 14: 2955-8 (2004) Article DOI: 10.1016/j.bmcl.2004.03.021 BindingDB Entry DOI: 10.7270/Q2M044W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1 (Bos taurus-BOVINE) | BDBM50146545 (2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against phosphodiesterase 1 from bovine, calmodulin | Bioorg Med Chem Lett 14: 2955-8 (2004) Article DOI: 10.1016/j.bmcl.2004.03.021 BindingDB Entry DOI: 10.7270/Q2M044W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 2A (Rattus norvegicus) | BDBM50146545 (2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against phosphodiesterase 2 from rat kidney | Bioorg Med Chem Lett 14: 2955-8 (2004) Article DOI: 10.1016/j.bmcl.2004.03.021 BindingDB Entry DOI: 10.7270/Q2M044W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50146545 (2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against phosphodiesterase 3 from human platelet | Bioorg Med Chem Lett 14: 2955-8 (2004) Article DOI: 10.1016/j.bmcl.2004.03.021 BindingDB Entry DOI: 10.7270/Q2M044W1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 4 (RAT-Rattus norvegicus) | BDBM50146545 (2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidney | Bioorg Med Chem Lett 14: 2955-8 (2004) Article DOI: 10.1016/j.bmcl.2004.03.021 BindingDB Entry DOI: 10.7270/Q2M044W1 | |||||||||||
More data for this Ligand-Target Pair |