BDBM50146552 2-[7-Ethyl-6-(4-sulfamoyl-benzylamino)-7H-purin-2-ylamino]-4-methyl-thiazole-5-carboxylic acid ethyl ester::CHEMBL100503::ethyl 2-(7-ethyl-6-(4-sulfamoylbenzylamino)-7H-purin-2-ylamino)-4-methylthiazole-5-carboxylate
SMILES: CCOC(=O)c1sc(Nc2nc(NCc3ccc(cc3)S(N)(=O)=O)c3n(CC)cnc3n2)nc1C
InChI Key: InChIKey=QNLOLWMFEMGKAI-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50146552 (2-[7-Ethyl-6-(4-sulfamoyl-benzylamino)-7H-purin-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of Phosphodiesterase 2 | Bioorg Med Chem Lett 15: 1829-33 (2005) Article DOI: 10.1016/j.bmcl.2005.02.025 BindingDB Entry DOI: 10.7270/Q2W37X3W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 3 (Homo sapiens (Human)) | BDBM50146552 (2-[7-Ethyl-6-(4-sulfamoyl-benzylamino)-7H-purin-2-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of Phosphodiesterase 3 | Bioorg Med Chem Lett 15: 1829-33 (2005) Article DOI: 10.1016/j.bmcl.2005.02.025 BindingDB Entry DOI: 10.7270/Q2W37X3W | |||||||||||
More data for this Ligand-Target Pair |