BDBM50146801 (cyclohexylamino)carbonylphosphonic acid::CHEMBL329784
SMILES: OP(O)(=O)C(=O)NC1CCCCC1
InChI Key: InChIKey=QQRCALUVCOFAOX-UHFFFAOYSA-N
Data: 10 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interstitial collagenase (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-1 was determined | J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-3 was determined | J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-8 was determined | J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-9 was determined | J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description Inhibition of MMP2 | J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 12 (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description Inhibition of human Carbonic anhydrase 12-mediated CO2 hydration by stopped-flow method | J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 9 (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description Inhibition of human Carbonic anhydrase 9-mediated CO2 hydration by stopped-flow method | J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description Inhibition of human Carbonic anhydrase 2-mediated CO2 hydration by stopped-flow method | J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description Inhibition of human Carbonic anhydrase 1-mediated CO2 hydration by stopped-flow method | J Med Chem 55: 7875-82 (2012) Article DOI: 10.1021/jm300981b BindingDB Entry DOI: 10.7270/Q23T9JBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50146801 ((cyclohexylamino)carbonylphosphonic acid | CHEMBL3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem Curated by ChEMBL | Assay Description In vitro inhibitory activity against recombinant matrix metalloprotease-2 was determined | J Med Chem 47: 2826-32 (2004) Article DOI: 10.1021/jm030386z BindingDB Entry DOI: 10.7270/Q2XS5W4C | |||||||||||
More data for this Ligand-Target Pair |