BDBM50147092 8-Amino-naphthalene-2-carboxamidine::8-amino-2-naphthimidamide::CHEMBL319264::uPa_15

SMILES: NC(=N)c1ccc2cccc(N)c2c1

InChI Key: InChIKey=JXOUQPJAWDJHOP-UHFFFAOYSA-N

Data: 9 KI

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50147092   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Trypsin-1 (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against trypsin				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PDB PubMed	450	-8.65	n/a	n/a	n/a	n/a	n/a	7.4	25
CSAR					Assay Description Abbott uPA__Urokinase Human - Ki(uM)				CSAR 1: (2012)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PDB D3R	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
D3R					Assay Description Photometric_Method1				D3R 227: (2015) BindingDB Entry DOI: 10.7270/Q24B305P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Urokinase-type plasminogen activator (urokinase)				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of urokinase				J Med Chem 52: 3159-65 (2009) Article DOI: 10.1021/jm801444x BindingDB Entry DOI: 10.7270/Q2FF3TM8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kallikrein 1 (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards P-kallikrein				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against thrombin				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against plasmin				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50147092 (8-Amino-naphthalene-2-carboxamidine | 8-amino-2-na...) Show SMILES NC(=N)c1ccc2cccc(N)c2c1 Show InChI InChI=1S/C11H11N3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h1-6H,12H2,(H3,13,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity towards tissue type plasminogen activator				Bioorg Med Chem Lett 14: 3063-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG
					More data for this Ligand-Target Pair