BDBM50148657 7-Ethoxy-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline::7-ethoxy-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline::CHEMBL120587

SMILES: CCOc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1cccc(C)n1

InChI Key: InChIKey=SGMXHEIWJQTVMJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50148657   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thyroid hormone receptor beta (Homo sapiens (Human))	BDBM50148657 (7-Ethoxy-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...) Show SMILES CCOc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1cccc(C)n1 |(-1.9,-4.25,;-2.4,-2.8,;-1.4,-1.64,;.1,-1.92,;1.12,-.75,;2.62,-1.05,;3.13,-2.5,;4.64,-2.8,;5.15,-4.25,;4.13,-5.41,;2.63,-5.13,;2.13,-3.67,;.61,-3.39,;5.65,-1.63,;5.15,-.17,;3.88,.71,;4.34,2.21,;5.87,2.21,;6.37,.76,;7.63,-.12,;7.18,-1.59,;8.18,-2.78,;7.64,-4.22,;8.62,-5.4,;10.14,-5.15,;10.68,-3.7,;12.19,-3.45,;9.7,-2.52,)| Show InChI InChI=1S/C23H22N4O/c1-3-28-16-9-10-17-18(11-12-24-20(17)14-16)22-21-8-5-13-27(21)26-23(22)19-7-4-6-15(2)25-19/h4,6-7,9-12,14H,3,5,8,13H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibitory activity against TGF-beta type I receptor				Bioorg Med Chem Lett 14: 3585-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.065 BindingDB Entry DOI: 10.7270/Q23R0SCK
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50148657 (7-Ethoxy-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...) Show SMILES CCOc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1cccc(C)n1 |(-1.9,-4.25,;-2.4,-2.8,;-1.4,-1.64,;.1,-1.92,;1.12,-.75,;2.62,-1.05,;3.13,-2.5,;4.64,-2.8,;5.15,-4.25,;4.13,-5.41,;2.63,-5.13,;2.13,-3.67,;.61,-3.39,;5.65,-1.63,;5.15,-.17,;3.88,.71,;4.34,2.21,;5.87,2.21,;6.37,.76,;7.63,-.12,;7.18,-1.59,;8.18,-2.78,;7.64,-4.22,;8.62,-5.4,;10.14,-5.15,;10.68,-3.7,;12.19,-3.45,;9.7,-2.52,)| Show InChI InChI=1S/C23H22N4O/c1-3-28-16-9-10-17-18(11-12-24-20(17)14-16)22-21-8-5-13-27(21)26-23(22)19-7-4-6-15(2)25-19/h4,6-7,9-12,14H,3,5,8,13H2,1-2H3	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of TGFR1				Eur J Med Chem 44: 4259-65 (2009) Article DOI: 10.1016/j.ejmech.2009.07.008 BindingDB Entry DOI: 10.7270/Q2BC3ZM9
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50148657 (7-Ethoxy-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...) Show SMILES CCOc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1cccc(C)n1 |(-1.9,-4.25,;-2.4,-2.8,;-1.4,-1.64,;.1,-1.92,;1.12,-.75,;2.62,-1.05,;3.13,-2.5,;4.64,-2.8,;5.15,-4.25,;4.13,-5.41,;2.63,-5.13,;2.13,-3.67,;.61,-3.39,;5.65,-1.63,;5.15,-.17,;3.88,.71,;4.34,2.21,;5.87,2.21,;6.37,.76,;7.63,-.12,;7.18,-1.59,;8.18,-2.78,;7.64,-4.22,;8.62,-5.4,;10.14,-5.15,;10.68,-3.7,;12.19,-3.45,;9.7,-2.52,)| Show InChI InChI=1S/C23H22N4O/c1-3-28-16-9-10-17-18(11-12-24-20(17)14-16)22-21-8-5-13-27(21)26-23(22)19-7-4-6-15(2)25-19/h4,6-7,9-12,14H,3,5,8,13H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38				Bioorg Med Chem Lett 14: 3585-8 (2004) Article DOI: 10.1016/j.bmcl.2004.04.065 BindingDB Entry DOI: 10.7270/Q23R0SCK
					More data for this Ligand-Target Pair