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BDBM50148869 CHEMBL3770643

SMILES: N[C@@H](Cc1c(Cl)cc(O)cc1Cl)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12

InChI Key: InChIKey=WNLHEKJUSTXAKY-SRTWOQSHNA-N

Data: 3 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50148869   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50148869
PNG
(CHEMBL3770643)
Show SMILES N[C@@H](Cc1c(Cl)cc(O)cc1Cl)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12 |r|
Show InChI InChI=1/C25H25Cl2N3O2/c26-20-12-17(31)13-21(27)18(20)14-22(28)25(32)30-24-8-9-29-23-7-6-16(11-19(23)24)10-15-4-2-1-3-5-15/h1-7,11-13,22,24,29,31H,8-10,14,28H2,(H,30,32)/t22-,24+/s2
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PC sid
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0.470n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from rat MOR expressed in rat C6 cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50148869
PNG
(CHEMBL3770643)
Show SMILES N[C@@H](Cc1c(Cl)cc(O)cc1Cl)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12 |r|
Show InChI InChI=1/C25H25Cl2N3O2/c26-20-12-17(31)13-21(27)18(20)14-22(28)25(32)30-24-8-9-29-23-7-6-16(11-19(23)24)10-15-4-2-1-3-5-15/h1-7,11-13,22,24,29,31H,8-10,14,28H2,(H,30,32)/t22-,24+/s2
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35n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOR expressed in CHO cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)

More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50148869
PNG
(CHEMBL3770643)
Show SMILES N[C@@H](Cc1c(Cl)cc(O)cc1Cl)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12 |r|
Show InChI InChI=1/C25H25Cl2N3O2/c26-20-12-17(31)13-21(27)18(20)14-22(28)25(32)30-24-8-9-29-23-7-6-16(11-19(23)24)10-15-4-2-1-3-5-15/h1-7,11-13,22,24,29,31H,8-10,14,28H2,(H,30,32)/t22-,24+/s2
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37n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from rat DOR expressed in rat C6 cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50148869
PNG
(CHEMBL3770643)
Show SMILES N[C@@H](Cc1c(Cl)cc(O)cc1Cl)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12 |r|
Show InChI InChI=1/C25H25Cl2N3O2/c26-20-12-17(31)13-21(27)18(20)14-22(28)25(32)30-24-8-9-29-23-7-6-16(11-19(23)24)10-15-4-2-1-3-5-15/h1-7,11-13,22,24,29,31H,8-10,14,28H2,(H,30,32)/t22-,24+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at human KOR expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay


ACS Med Chem Lett 6: 1199-203 (2015)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50148869
PNG
(CHEMBL3770643)
Show SMILES N[C@@H](Cc1c(Cl)cc(O)cc1Cl)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12 |r|
Show InChI InChI=1/C25H25Cl2N3O2/c26-20-12-17(31)13-21(27)18(20)14-22(28)25(32)30-24-8-9-29-23-7-6-16(11-19(23)24)10-15-4-2-1-3-5-15/h1-7,11-13,22,24,29,31H,8-10,14,28H2,(H,30,32)/t22-,24+/s2
PDB

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PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 33n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat MOR expressed in rat C6 cells after 1 hr by [35S]GTPgammaS binding assay


ACS Med Chem Lett 6: 1199-203 (2015)

More data for this
Ligand-Target Pair