BDBM50149088 3-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-yl]-N-[3-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-propionamide::CHEMBL122102

SMILES: Fc1cc(NC(=O)CCc2ccc3nc([nH]c3c2)-c2ccc(Cl)s2)ccc1-n1ccccc1=O

InChI Key: InChIKey=SMTWGERLMINIGO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50149088   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM50149088 (3-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-y...) Show SMILES Fc1cc(NC(=O)CCc2ccc3nc([nH]c3c2)-c2ccc(Cl)s2)ccc1-n1ccccc1=O Show InChI InChI=1S/C25H18ClFN4O2S/c26-22-10-9-21(34-22)25-29-18-7-4-15(13-19(18)30-25)5-11-23(32)28-16-6-8-20(17(27)14-16)31-12-2-1-3-24(31)33/h1-4,6-10,12-14H,5,11H2,(H,28,32)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity of the compoumd to human coagulation factor Xa				Bioorg Med Chem Lett 14: 3763-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.097 BindingDB Entry DOI: 10.7270/Q25H7FQS
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50149088 (3-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-y...) Show SMILES Fc1cc(NC(=O)CCc2ccc3nc([nH]c3c2)-c2ccc(Cl)s2)ccc1-n1ccccc1=O Show InChI InChI=1S/C25H18ClFN4O2S/c26-22-10-9-21(34-22)25-29-18-7-4-15(13-19(18)30-25)5-11-23(32)28-16-6-8-20(17(27)14-16)31-12-2-1-3-24(31)33/h1-4,6-10,12-14H,5,11H2,(H,28,32)(H,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity against human thrombin.				Bioorg Med Chem Lett 14: 3763-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.097 BindingDB Entry DOI: 10.7270/Q25H7FQS
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50149088 (3-[2-(5-Chloro-thiophen-2-yl)-1H-benzoimidazol-5-y...) Show SMILES Fc1cc(NC(=O)CCc2ccc3nc([nH]c3c2)-c2ccc(Cl)s2)ccc1-n1ccccc1=O Show InChI InChI=1S/C25H18ClFN4O2S/c26-22-10-9-21(34-22)25-29-18-7-4-15(13-19(18)30-25)5-11-23(32)28-16-6-8-20(17(27)14-16)31-12-2-1-3-24(31)33/h1-4,6-10,12-14H,5,11H2,(H,28,32)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Binding affinity of the compoumd against human trypsin was determined				Bioorg Med Chem Lett 14: 3763-9 (2004) Article DOI: 10.1016/j.bmcl.2004.04.097 BindingDB Entry DOI: 10.7270/Q25H7FQS
					More data for this Ligand-Target Pair