BDBM50149899 CHEMBL3770788

SMILES: CCN(C1CCOCC1)c1cc(Cl)cc(C(=O)NCc2ccc(C)[nH]c2=O)c1C

InChI Key: InChIKey=ZRUQKPSGZKVRJH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50149899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50149899 (CHEMBL3770788) Show SMILES CCN(C1CCOCC1)c1cc(Cl)cc(C(=O)NCc2ccc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H28ClN3O3/c1-4-26(18-7-9-29-10-8-18)20-12-17(23)11-19(15(20)3)22(28)24-13-16-6-5-14(2)25-21(16)27/h5-6,11-12,18H,4,7-10,13H2,1-3H3,(H,24,28)(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme Curated by ChEMBL					Assay Description Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay				J Med Chem 59: 1556-64 (2016) BindingDB Entry DOI: 10.7270/Q2B56MM7
					More data for this Ligand-Target Pair