BDBM50149913 CHEMBL3770270

SMILES: Cc1nn(C)cc1Oc1nc2cnccc2c(=O)[nH]1

InChI Key: InChIKey=CDFNDYAUXUMVJA-DEOSSOPVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50149913   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM50149913 (CHEMBL3770270) Show SMILES Cc1nn(C)cc1Oc1nc2cnccc2c(=O)[nH]1 Show InChI InChI=1S/C28H29BrN4O4/c29-22-12-13-25(30-17-22)32-26(35)16-24(28(37)33-14-4-1-5-15-33)31-27(36)20-10-8-19(9-11-20)23-7-3-2-6-21(23)18-34/h2-3,6-13,17,24,34H,1,4-5,14-16,18H2,(H,31,36)(H,30,32,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	<1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of N-terminal his-tagged full-length human KDM4C transfected in U2OS cells assessed as inhibition of H3K9Me3 demethylation for 24 hrs				J Med Chem 59: 1370-87 (2016) BindingDB Entry DOI: 10.7270/Q26D5VV2
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM50149913 (CHEMBL3770270) Show SMILES Cc1nn(C)cc1Oc1nc2cnccc2c(=O)[nH]1 Show InChI InChI=1S/C28H29BrN4O4/c29-22-12-13-25(30-17-22)32-26(35)16-24(28(37)33-14-4-1-5-15-33)31-27(36)20-10-8-19(9-11-20)23-7-3-2-6-21(23)18-34/h2-3,6-13,17,24,34H,1,4-5,14-16,18H2,(H,31,36)(H,30,32,35)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of N-terminal his-tagged human KDM4C expressed in Escherichia coli BL21(DE3) using trimethylated peptide substrate by RFMS assay				J Med Chem 59: 1370-87 (2016) BindingDB Entry DOI: 10.7270/Q26D5VV2
					More data for this Ligand-Target Pair