BDBM50150057 2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamide::CHEMBL184717

SMILES: CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1

InChI Key: InChIKey=OKIVGPUCUWMOIH-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50150057   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50150057 (2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...) Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Argenta Discovery Ltd. Curated by ChEMBL					Assay Description Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells				J Med Chem 47: 3962-71 (2004) Article DOI: 10.1021/jm040762v BindingDB Entry DOI: 10.7270/Q2668CP3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50150057 (2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...) Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Argenta Discovery Limited Curated by ChEMBL					Assay Description Inhibitory activity against human 5-HT2A receptor				Bioorg Med Chem Lett 14: 4099-102 (2004) Article DOI: 10.1016/j.bmcl.2004.05.051 BindingDB Entry DOI: 10.7270/Q2WW7H49
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50150057 (2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...) Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50150057 (2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...) Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	349	n/a	n/a	n/a	n/a	n/a	n/a
Argenta Discovery Limited Curated by ChEMBL					Assay Description Inhibitory activity against human 5-HT2B receptor				Bioorg Med Chem Lett 14: 4099-102 (2004) Article DOI: 10.1016/j.bmcl.2004.05.051 BindingDB Entry DOI: 10.7270/Q2WW7H49
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50150057 (2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...) Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Argenta Discovery Limited Curated by ChEMBL					Assay Description Inhibitory activity against human 5-HT2C receptor				Bioorg Med Chem Lett 14: 4099-102 (2004) Article DOI: 10.1016/j.bmcl.2004.05.051 BindingDB Entry DOI: 10.7270/Q2WW7H49
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50150057 (2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...) Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Argenta Discovery Limited Curated by ChEMBL					Assay Description Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1R				Bioorg Med Chem Lett 14: 4099-102 (2004) Article DOI: 10.1016/j.bmcl.2004.05.051 BindingDB Entry DOI: 10.7270/Q2WW7H49
					More data for this Ligand-Target Pair