BDBM50150176 CHEMBL340163::Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-[(furan-2-carbonyl)-amino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl ester
SMILES: CO[C@H]1CC(C)=Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2NC(=O)c1ccco1
InChI Key: InChIKey=QIQUKXVYMWJPDI-LOUZXUARSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human)) | BDBM50150176 (CHEMBL340163 | Carbamic acid (4E,6Z,10E)-(8S,9S,12...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Conforma Therapeutics Corporation Curated by ChEMBL | Assay Description Inhibition of human epidermal growth factor 2 (Her-2) degredation in MCF-7 cells | J Med Chem 47: 3865-73 (2004) Article DOI: 10.1021/jm0306125 BindingDB Entry DOI: 10.7270/Q2NC60N3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human)) | BDBM50150176 (CHEMBL340163 | Carbamic acid (4E,6Z,10E)-(8S,9S,12...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Conforma Therapeutics Corporation Curated by ChEMBL | Assay Description Concentration required to inhibit biotin-GM binding to recombinant heat shock protein 90(rHsp90) | J Med Chem 47: 3865-73 (2004) Article DOI: 10.1021/jm0306125 BindingDB Entry DOI: 10.7270/Q2NC60N3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat Shock Protein 90 (Hsp90) (Homo sapiens (Human)) | BDBM50150176 (CHEMBL340163 | Carbamic acid (4E,6Z,10E)-(8S,9S,12...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Conforma Therapeutics Corporation Curated by ChEMBL | Assay Description Concentration required to inhbit Bis-ANS activity by recombinant heat shock protein 90 (rHSP90) conformational assay | J Med Chem 47: 3865-73 (2004) Article DOI: 10.1021/jm0306125 BindingDB Entry DOI: 10.7270/Q2NC60N3 | |||||||||||
More data for this Ligand-Target Pair |