BDBM50150622 CHEMBL184587::Hexanedioic acid {4-[3,6-bis-(3-pyrrolidin-1-yl-propionylamino)-acridin-9-ylamino]-phenyl}-amide (2-diethylamino-ethyl)-amide::N1-(4-(3,6-bis(3-(pyrrolidin-1-yl)propanamido)acridin-9-ylamino)phenyl)-N6-(2-(diethylamino)ethyl)adipamide
SMILES: CCN(CC)CCNC(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
InChI Key: InChIKey=OHRRVGUOAWHKDN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50150622 (CHEMBL184587 | Hexanedioic acid {4-[3,6-bis-(3-pyr...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas Curated by ChEMBL | Assay Description Inhibition of telomerase in human A2780 cells by TRAP assay | Eur J Med Chem 44: 4826-40 (2009) Article DOI: 10.1016/j.ejmech.2009.07.029 BindingDB Entry DOI: 10.7270/Q20R9PHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50150622 (CHEMBL184587 | Hexanedioic acid {4-[3,6-bis-(3-pyr...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 98 | n/a | n/a | n/a | n/a |
University of London School of Pharmacy Curated by ChEMBL | Assay Description Effective concentration against telomerase by TRAP | Bioorg Med Chem Lett 14: 4347-51 (2004) Article DOI: 10.1016/j.bmcl.2004.05.090 BindingDB Entry DOI: 10.7270/Q2KD1XDZ | |||||||||||
More data for this Ligand-Target Pair |