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BDBM50151045 1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine::CHEMBL435505

SMILES: C(CN1CCCC1)Oc1ccccc1Cc1ccccc1

InChI Key: InChIKey=MNZXCYDDVWTITD-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50151045   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50151045
PNG
(1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-2-8-17(9-3-1)16-18-10-4-5-11-19(18)21-15-14-20-12-6-7-13-20/h1-5,8-11H,6-7,12-16H2
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16n/an/an/an/an/an/an/an/a



Vrije Universiteit Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by m...


J Med Chem 59: 9047-9061 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00981
BindingDB Entry DOI: 10.7270/Q2G44S8Z
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50151045
PNG
(1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-2-8-17(9-3-1)16-18-10-4-5-11-19(18)21-15-14-20-12-6-7-13-20/h1-5,8-11H,6-7,12-16H2
KEGG

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379n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D1


J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50151045
PNG
(1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-2-8-17(9-3-1)16-18-10-4-5-11-19(18)21-15-14-20-12-6-7-13-20/h1-5,8-11H,6-7,12-16H2
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951n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D5


J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50151045
PNG
(1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-2-8-17(9-3-1)16-18-10-4-5-11-19(18)21-15-14-20-12-6-7-13-20/h1-5,8-11H,6-7,12-16H2
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1.43E+3n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D4.4


J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50151045
PNG
(1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-2-8-17(9-3-1)16-18-10-4-5-11-19(18)21-15-14-20-12-6-7-13-20/h1-5,8-11H,6-7,12-16H2
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1.82E+3n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D3


J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50151045
PNG
(1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-2-8-17(9-3-1)16-18-10-4-5-11-19(18)21-15-14-20-12-6-7-13-20/h1-5,8-11H,6-7,12-16H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D2L


J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair