BDBM50151244 CHEMBL3770688
SMILES: Cc1cc(ccc1N1CCN(CC1)S(=O)(=O)N[C@H](CCCNC(=O)OCc1ccccc1)C(=O)NO)C#N
InChI Key: InChIKey=FWILDXURZVZYSC-JOCHJYFZSA-N
Data: 17 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-17 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of human MMP-1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assay | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP-2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assay | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP-9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assay | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of recombinant human MMP-14 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 3 hrs by fluorometric assay | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 30 mins by fluorometric assay | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 1 hr by fluorometric assay | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human L428 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-17 in human L428 cells assessed as reduction in pervanadate-induced soluble ALCAM shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble ULBP3 shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human L540 cells assessed as reduction in pervanadate-induced soluble MICB shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human)) | BDBM50151244 (CHEMBL3770688) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
San Raffaele Scientific Institute Curated by ChEMBL | Assay Description Inhibition of ADAM-10 in human KM-H2 cells assessed as reduction in pervanadate-induced TNFalpha shedding after 24 hrs by ELISA | Eur J Med Chem 111: 193-201 (2016) BindingDB Entry DOI: 10.7270/Q2765H73 | |||||||||||
More data for this Ligand-Target Pair |