BDBM50151509 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-((1S,2S)-2-[1,2,4]triazol-1-yl-cyclohexyl)-piperazin-1-yl]-ethyl}-amide::CHEMBL362670

SMILES: Clc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCN(CC2)[C@H]2CCCC[C@@H]2n2cncn2)cc1

InChI Key: InChIKey=OUXUPILGGCGFJJ-FDYVXIQZSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50151509   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50151509 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCN(CC2)[C@H]2CCCC[C@@H]2n2cncn2)cc1 Show InChI InChI=1S/C31H38ClN7O2/c32-25-11-9-22(10-12-25)17-27(36-30(40)26-18-23-5-1-2-6-24(23)19-34-26)31(41)38-15-13-37(14-16-38)28-7-3-4-8-29(28)39-21-33-20-35-39/h1-2,5-6,9-12,20-21,26-29,34H,3-4,7-8,13-19H2,(H,36,40)/t26?,27-,28+,29+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Binding affinity towards Melanocortin 4 receptor using [125I]NDP-MSH				J Med Chem 47: 4613-26 (2004) Article DOI: 10.1021/jm0311285 BindingDB Entry DOI: 10.7270/Q2BR8RNZ
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM50151509 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCN(CC2)[C@H]2CCCC[C@@H]2n2cncn2)cc1 Show InChI InChI=1S/C31H38ClN7O2/c32-25-11-9-22(10-12-25)17-27(36-30(40)26-18-23-5-1-2-6-24(23)19-34-26)31(41)38-15-13-37(14-16-38)28-7-3-4-8-29(28)39-21-33-20-35-39/h1-2,5-6,9-12,20-21,26-29,34H,3-4,7-8,13-19H2,(H,36,40)/t26?,27-,28+,29+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Binding affinity towards Melanocortin 1 receptor using [125I]NDP-MSH				J Med Chem 47: 4613-26 (2004) Article DOI: 10.1021/jm0311285 BindingDB Entry DOI: 10.7270/Q2BR8RNZ
					More data for this Ligand-Target Pair
Melanocortin receptor 3 (Homo sapiens (Human))	BDBM50151509 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCN(CC2)[C@H]2CCCC[C@@H]2n2cncn2)cc1 Show InChI InChI=1S/C31H38ClN7O2/c32-25-11-9-22(10-12-25)17-27(36-30(40)26-18-23-5-1-2-6-24(23)19-34-26)31(41)38-15-13-37(14-16-38)28-7-3-4-8-29(28)39-21-33-20-35-39/h1-2,5-6,9-12,20-21,26-29,34H,3-4,7-8,13-19H2,(H,36,40)/t26?,27-,28+,29+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Binding affinity towards Melanocortin 3 receptor using [125I]NDP-MSH				J Med Chem 47: 4613-26 (2004) Article DOI: 10.1021/jm0311285 BindingDB Entry DOI: 10.7270/Q2BR8RNZ
					More data for this Ligand-Target Pair
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human))	BDBM50151509 (1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...) Show SMILES Clc1ccc(C[C@@H](NC(=O)C2Cc3ccccc3CN2)C(=O)N2CCN(CC2)[C@H]2CCCC[C@@H]2n2cncn2)cc1 Show InChI InChI=1S/C31H38ClN7O2/c32-25-11-9-22(10-12-25)17-27(36-30(40)26-18-23-5-1-2-6-24(23)19-34-26)31(41)38-15-13-37(14-16-38)28-7-3-4-8-29(28)39-21-33-20-35-39/h1-2,5-6,9-12,20-21,26-29,34H,3-4,7-8,13-19H2,(H,36,40)/t26?,27-,28+,29+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Binding affinity towards Melanocortin 5 receptor using [125I]NDP-MSH				J Med Chem 47: 4613-26 (2004) Article DOI: 10.1021/jm0311285 BindingDB Entry DOI: 10.7270/Q2BR8RNZ
					More data for this Ligand-Target Pair