BDBM50151909 3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitrile::CHEMBL361795
SMILES: N#Cc1cccc(c1)-c1nc(no1)-c1ccccn1
InChI Key: InChIKey=KZOBYFBUONCLFZ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Metabotropic glutamate receptor (Rattus norvegicus (Rat)) | BDBM50151909 (3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from glutamate 5 receptor of rat cortical membranes | J Med Chem 47: 4645-8 (2004) Article DOI: 10.1021/jm049828c BindingDB Entry DOI: 10.7270/Q2DJ5F3G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50151909 (3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel... | Bioorg Med Chem Lett 22: 6974-9 (2012) Article DOI: 10.1016/j.bmcl.2012.08.100 BindingDB Entry DOI: 10.7270/Q2BP03WH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50151909 (3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory concentration towards human glutamate receptor 5 in calcium flux assay | J Med Chem 47: 4645-8 (2004) Article DOI: 10.1021/jm049828c BindingDB Entry DOI: 10.7270/Q2DJ5F3G | |||||||||||
More data for this Ligand-Target Pair |