BDBM50152131 CHEMBL3781917
SMILES: Cc1cnc(N)nc1NCC(C)(C)CO
InChI Key: InChIKey=COFDBDASTPVGGW-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MutT homolog 1 protein (MTH1) (Homo sapiens (Human)) | BDBM50152131 (CHEMBL3781917) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
MD Anderson Cancer Center Curated by ChEMBL | Assay Description Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assay | Bioorg Med Chem Lett 26: 1503-7 (2016) BindingDB Entry DOI: 10.7270/Q20K2BF6 | |||||||||||
More data for this Ligand-Target Pair |