BDBM50152154 CHEMBL3780876

SMILES: OC(=O)c1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2cccc(F)c2)cc1

InChI Key: InChIKey=ZUPKANHHZSOGLA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50152154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50152154 (CHEMBL3780876) Show SMILES OC(=O)c1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2cccc(F)c2)cc1 Show InChI InChI=1S/C23H15ClFNO4/c24-17-8-4-15(5-9-17)20-21(23(27)28)26-30-22(20)16-6-10-19(11-7-16)29-13-14-2-1-3-18(25)12-14/h1-12H,13H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 assessed as 5-LO product formation preincubated for 15 mins followed by addit...				Eur J Med Chem 113: 1-10 (2016) BindingDB Entry DOI: 10.7270/Q2BV7JHB
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM50152154 (CHEMBL3780876) Show SMILES OC(=O)c1noc(c1-c1ccc(Cl)cc1)-c1ccc(OCc2cccc(F)c2)cc1 Show InChI InChI=1S/C23H15ClFNO4/c24-17-8-4-15(5-9-17)20-21(23(27)28)26-30-22(20)16-6-10-19(11-7-16)29-13-14-2-1-3-18(25)12-14/h1-12H,13H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gazi University Curated by ChEMBL					Assay Description Inhibition of FLAP in Ca+2 ionophore A23187 stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 1...				Eur J Med Chem 113: 1-10 (2016) BindingDB Entry DOI: 10.7270/Q2BV7JHB
					More data for this Ligand-Target Pair