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SMILES: CCCN(Cc1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C

InChI Key: InChIKey=PFUUOOOSLMHWRW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152172   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50152172
PNG
(Benzyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-...)
Show SMILES CCCN(Cc1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(6.68,-1.14,;5.18,-.82,;4.68,.63,;3.18,.95,;2.71,2.4,;3.73,3.56,;3.23,5.02,;4.25,6.16,;5.76,5.87,;6.25,4.39,;5.23,3.24,;2.15,-.21,;2.64,-1.66,;1.61,-2.81,;2.1,-4.27,;.12,-2.5,;-.37,-1.03,;-1.77,-.4,;-1.63,1.12,;-2.78,2.14,;-.12,1.45,;.65,.11,;-3.1,-1.19,;-3.1,-2.74,;-4.43,-3.51,;-5.76,-2.74,;-5.76,-1.2,;-4.43,-.4,;-4.45,1.12,;-7.09,-3.51,;-8.44,-2.74,;-7.09,-5.05,)|
Show InChI InChI=1S/C26H32N6/c1-7-13-31(17-21-11-9-8-10-12-21)24-15-19(3)28-26-25(20(4)29-32(24)26)22-16-27-23(30(5)6)14-18(22)2/h8-12,14-16H,7,13,17H2,1-6H3
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Article
PubMed
 5.20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor

J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair