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SMILES: CCCN(c1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C

InChI Key: InChIKey=POCSEWJXFBBHHG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50152182   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50152182
PNG
(CHEMBL184752 | [3-(6-Dimethylamino-4-methyl-pyridi...)
Show SMILES CCCN(c1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(7.25,-.89,;5.74,-.59,;5.25,.88,;3.76,1.18,;3.27,2.65,;4.29,3.79,;3.81,5.24,;2.31,5.56,;1.29,4.4,;1.76,2.95,;2.73,.04,;3.2,-1.42,;2.17,-2.57,;2.66,-4.03,;.68,-2.24,;.19,-.8,;-1.2,-.17,;-1.04,1.35,;-2.21,2.37,;.45,1.68,;1.22,.34,;-2.53,-.96,;-2.53,-2.5,;-3.86,-3.27,;-5.19,-2.5,;-5.19,-.96,;-3.86,-.17,;-3.86,1.35,;-6.52,-3.27,;-6.52,-4.81,;-7.84,-2.5,)|
Show InChI InChI=1S/C25H30N6/c1-7-13-30(20-11-9-8-10-12-20)23-15-18(3)27-25-24(19(4)28-31(23)25)21-16-26-22(29(5)6)14-17(21)2/h8-12,14-16H,7,13H2,1-6H3
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Article
PubMed
 8.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor

J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair